C-Met inhibitor - definizione. Che cos'è C-Met inhibitor
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Cosa (chi) è C-Met inhibitor - definizione


C-Met inhibitor         
  • Figure 7. MK2461, a unique c-Met inhibitor
  • Figure 2. PHA665752, a second-generation c-Met inhibitor.
  • Figure 1. SU11274, a first generation c-Met inhibitor (indolin-2-one core in red circle).
  • [[Tivantinib]] (ARQ197), a c-Met inhibitor
CLASS OF COMPOUNDS
Discovery and development of small molecule c-Met inhibitors; C-Met inhibitors; MET inhibitor
c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF). These inhibitors may have therapeutic application in the treatment of various types of cancers.
C-Met         
  • Interplay between MET, beta catenin, Wnt, and Notch signaling pathways<ref name="Abounader_2004"/>
  • MET signaling complex<ref name="Abounader_2004"/>
  • Schematic structure of MET protein <ref name="Gentile_2008"/>
  • Strategies to inhibit biological activity of MET <ref name="Gentile_2008"/>
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
Proto-oncogene proteins c-met; HGFR; C-MET; Hgfr; RCCP2; Rccp2; Met proto-oncogene; Hepatocyte growth factor receptor; MET (gene); MET kinase
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity.
Polymerisation inhibitor         
CHEMICAL ADDITIVE THAT SUPPRESSES POLYMERIZATION
Polymerization inhibitor
Polymerisation inhibitors (US: polymerization inhibitors) are chemical compounds added to monomers to prevent their auto-polymerisation. Unsaturated monomers such as acrylates, vinyl chloride, butadiene and styrene require inhibitors for both processing and safe transport and storage.